Osteopenia and osteoporosis associated with hyperprolactinemic antipsychotics

Introduction The main role of prolactin is associated mainly with lactogenesis but additionally it participates in several endocrinological and metabolic processes. level may be increased some antipsychotics such as risperidone, paliperidone, amisulpride increasing the risk Bone Mineral Mass (BMM) decrease leading to osteopenia osteoporosis. Objectives To determine loss BMM antipsychotic-related iatrogenic hyperprolactinemia (iHPRL) a sample patients suffering chronic psychotic mental disorder treated at least for one year. Methods A cross-sectional observational epidemiological study 140 (males 56.9%; females 43.1%; mean age 48 years), receiving was carried out. After giving informed consent, personal data, level, antipsychotic use lifestyle were collected. An evaluation central DEXA Scan performed. bone mineral density considering subject´s peak mass neck femur, hip lumbar vertebrae (L1-L4) obtained. Inclusion criteria: presence disorder, between 18-65 years treatment an Statistical analysis out using statistical software SPSS version 26.0. significance α=0.05 considered throughout study. Results 45 (32,13%) had lost (osteopenia). prevalence osteoporosis 5.71% (n=8). median 46.1 ng/dL ± 33.1. Patients hyperprolactinaemia showed higher frequency osteopenia/osteoporosis (50% mild iHPRL 48% moderate/severe iHPRL) than those normal levels (25.7%). strong significant relationship risperidone found (p=0.007). Conclusions Osteopenia are hyperprolactinemic antipsychotic. Risperidone related risk. rutinary systematic control crucial these avoid progressive demineralization. Managing strategies should individualized demineralization preserve physical health. Disclosure Interest None Declared